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Enantiomer & Odor
Description
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Odour Threshold (PPB)
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Musk Odorants
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.
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(4S,7R)-(-)-galaxolide
- powerful musk odor
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0.00063 (in air)
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(4R,7S)-(+)-galaxolide
- weak to almost odorless
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0.13 (in air)
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(4R,7R)-(+)-galaxolide
- weak to almost odorless
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0.44 (in air)
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(4S,7S)-(-)-galaxolide
- powerful musk odor
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0.001 (in air)
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(R)-(-)-muscone
- rich, powerful, musky; very nice musky note, rich
and powerful,”
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61
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(S)-(+)-muscone
- poor, weakly musky
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233
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(12R,9Z)-
Nirvanolide®
- intense musky, fruity, powdery odor with lactonic
nuances
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0.05
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(12S,9Z)-
Nirvanolide®
- odorless
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odorless
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(+)-(11R)-11-methyl-12-dodecanolide
- a faint musk note with very fresh nuances of
clary sage and bergamot is accompanied by
cedar-wood accents. Only a slightly earthy-musty
undertone has to be accounted.
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NA
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(-)-(11S)-11-methyl-12-dodecanolide
- The smell of the (S)-enantiomer does not differ
much in its sensory qualities, however it is of
weaker intensity.
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NA
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(12S)-(-)-12-methyl-13-tridecanolide
- animalic, musky, camphoraceous
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NA
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(12R)-(+)-12-methyl-13-tridecanolide
- sandalwood-like musk note
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NA
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(12S,13R)-(-)-12-methyl-13-tetradecanolide
- animalic cedar wood profile with camphoraceous
aspects; devoid of musk notes
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NA
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(12R,13S)-(+)-12-methyl-13-tetradecanolide
- strong woody odor with a pronounced musk
character
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NA
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(12R)-(-)-12-methyl-9-oxa-14-tetradecanolide
- intense musky-floral, powdery odor reminiscent of
the nitro musk musk ambrette, with additional
woody, myrrh-type factors
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0.09
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(12S)-(+)-12-methyl-9-oxa-14-tetradecanolide
- odorless
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odorless
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(-)-(S)-Muscolide -
weak intensity, but possesses a very pleasant musk
note with a more distinctive erogenous-animalic
character.
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NA
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(+)-(R)-muscolide -
slightly erogenous, animalic, resembling that of
natural musk tincture.
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NA
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(-)-(S)-Oxo-muscolide
- possesses a weak musk note, without animalic
character, and is dominated by an odour reminiscent
of ironed linen.
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NA
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(+)-(R)-Oxo-muscolide
- slightly musky and sweet, but not
erogenous-animalic.
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NA
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(+)-(1'R,4S)-Helvetolide
- Odor properties: musky, ambrette, pear. The
fragrance effect imparted by the above-cited
preferred compound of the invention is even more
powerful and muskier when said compound is used in
the form of one of its optically active isomers,
i.e., (+)-Helvetolide
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1.1 ng/liter in air
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(-)-(1'S,4R)-Helvetolide
- Odor properties: nicely musky and ambrette, pear,
floral.
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NA
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(1S,1'R)-Romandolide®
or
(1S,1'R)-1-[(3',3'-dimethyl-1'-cyclohexyl)-ethoxycarbonyl]methyl
propanoate - The odor properties are best
represented in the enantiomer of the configuration
(1S, 1'R), which renders this compound a choice
ingredient of the invention. This compound
possesses a classical musky type odor, reminiscent
of that of Galaxolide®
(7,8-dihydro-4,6,6,7,8,8-hexamethyl-6H-cyclopenta[9]-2-benzopyrane;
and confers an olfactive impression which is that
of a sweet and natural musky odor, with a velvety
connotation, and which provides much volume. There
is also found a light ambrette nuance which is
accompanied by an undernote reminiscent of the odor
of green fruits.
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0.7 ng/liter in air
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(1R,1'S)-Romandolide®
or
(1R,1'S)-1-[(3',3'-dimethyl-1'-cyclohexyl)-ethoxycarbonyl]methyl
propanoate - This compound is less preferred
than the (1S, 1'R) enantiomer.
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NA
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(+)-(1S,1'R)-Rosamusk
- powerful rose/ionone character with fruity and
musk-like undertones
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NA
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(-)-(1R,1'S)-Rosamusk
- This compound is less preferred than the (1S,
1'R) enantiomer.
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NA
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(3S)-(-)-3-Methyl-1,4-dioxacyclopentadecan-2-one
- musk, sweet-flowery, ambergris, erogenous,
animalic, reminiscent of ambrette musk and
nitromusk, weaker than the enantiomer mixture.
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NA
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(3R)-(+)-3-Methyl-1,4-dioxacyclopentadecan-2-one
- musk, sweet-flowery, ambergris, erogenous,
animalic, reminiscent of ambrette musk and
nitromusk, stronger than the
(S)-(-)-enantiomer.
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NA
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(3S)-(-)-3-Methyl-1,4-dioxacyclohexadecan-2-one
- musk, sweet-woody, ambergris, erogenous,
animalic, reminiscent of ambrette musk and
nitromusk, weaker than the enantiomer mixture.
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NA
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(3R)-(+)-3-Methyl-1,4-dioxacyclohexadecan-2-one
- musk, sweet-woody, ambergris, erogenous,
animalic, reminiscent of ambrette musk and
nitromusk, stronger than the
(S)-(-)-enantiomer.
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NA
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(+)-(3R)-3,7-dimethyloct-6-enyl
ethyl oxalate - Floral musk
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200 ppb
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(-)-(3S)-3,7-dimethyloct-6-enyl
ethyl oxalate - Rose-like floral
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500 ppb
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(4R)-(-)-4-methyloxacyclopentadec-9-en-2-one
- Diffusive powdery musk odor
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NA
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(4S)-(+)-4-methyloxacyclopentadec-9-en-2-one
- Weak poor musk odor
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NA
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(3R)-(+)-3-Methyl-1,4-dioxa-(E/Z)-6-cyclopentadecen-2-one
- Odor: musk, sweet-flowery, ambergris, erogenous,
reminiscent of ambrette musk, more musk-like and
erogenous than the (S)-(-)-enantiomer.
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NA
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(3S)-(-)-3-Methyl-1,4-dioxa-(E/Z)-6-cyclopentadecen-2-one
- Odor: weakly musk, sweet-flowery, erogenous,
weaker than the enantiomer mixture.
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NA
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(3R)-(+)-3-Methyl-1,4-dioxa-(E/Z)-6-cyclohexadecen-2-one
- Odor: musk, sweet-woody, ambergris, erogenous,
animalic, reminiscent of ambrette musk, stronger
than the enantiomer mixture.
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NA
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(3S)-(-)-3-Methyl-1,4-dioxa-(E/Z)-6-cyclohexadecen-2-one
- Odor: weakly musk, sweet-woody, erogenous.
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NA
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(+)-(1R,3R)-Muscol -
strong musk scent and softness, excellent in
diffusibility, and had a graceful aroma for
musks
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NA
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(-)-(1S,3S)-Muscol -
aromatic, weak animal woody with slight
hay-rucksack smells, some fruity sweetness
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NA
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(-)-(1R,3S)-Muscol -
aromatic, weak animal woody with slight
hay-rucksack smells
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NA
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(+)-(1S,3R)-Muscol -
very weak musk scent,chemical-like
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NA
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(3S)-(-)-Fixolide -
strong musk
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NA
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(3R)-(+)-Fixolide -
light, sweet, aromatic
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NA
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(S,S)-(-)-Vulcanolide
- this enantiomer possesses the best developed odor
properties. Its musky, markedly earthy, slightly
amber character is particularly powerful.
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NA
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(R,R)-(+)-Vulcanolide
- this enantiomer develops a fragrance of a less
earthy character, with a woody side and the
strength of which is clearly inferior to the
(S,S)-enantiomer.
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NA
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(S,S)-(-)-Vulcanonitrile
- stronger earthy, musky and woodier note than its
(+)-(6R,7R) enantiomer.
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NA
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(R,R)-(+)-Vulcanonitrile
- similar, but less musky and woody than the
(-)-(6S,7S) enantiomer
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NA
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(-)-(3R,5Z)-3-methylcyclopentadec-5-en-1-one
- Strong and pure smell of musk with some sweaty
notes -
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NA
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(+)-(3S,5E)-3-methylcyclopentadec-5-en-1-one
- Weak musk with a little woody feeling
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NA
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(-)-(3R,5E)-3-methylcyclopentadec-5-en-1-one
- Strong and pure smell of musk
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NA
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(+)-(3S,5E)-3-methylcyclopentadec-5-en-1-one
- Weak musk with a little woody feeling
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NA
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(+)-(S)-13-Tetradecanolide
- Complex, woody-cedar, balsamic odor; very similar
to is enantiomer
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NA
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(-)-(R)-13-Tetradecanolide
- Complex, woody-cedar, balsamic odor; very similar
to is enantiomer
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NA
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Ethyl
(1S)-1-[(1'R)-3,3-dimethylcyclohexyl]ethyl
malonate - Powerful Musky, Fruity, Woody,
Ambery
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Rel. Odor Int. = 7.5
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Ethyl
(1RS)-1-[(1'RS)-3,3-dimethylcyclohexyl]ethyl
malonate - Fruity, Apple, Musky
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Rel. Odor Int. = 5.0
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Ethyl
(1S)-1-[(1'RS)-3,3-dimethylcyclohexyl]ethyl
malonate - Musky, Fruity, Honey, Woody,
Ambery
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Rel. Odor Int. = 6.0
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Ethyl
(1R)-1-[(1'RS)-3,3-dimethylcyclohexyl]ethyl
malonate - Masky, Dirty Honey, Fruity,
Woody
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Rel. Odor Int. = 4.0
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(R)-(+)-Tonalide -
light and sweet aromatic odor
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NA
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(S)-(-)-Tonalide -
strongly musky odor with a good fixation
property
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NA
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(14S)-14-ethyloxacyclotetradecan-2-one
- distinct woody, fresh and fruity, clearly
musk
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NA
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(14R)-14-ethyloxacyclotetradecan-2-one
- weak musk odour with a smell of burning, musty,
not fresh
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NA
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(17S)-17-ethyloxacycloheptadecan-2-one
- weak, a touch of musk, slightly woody and
fruity
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NA
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(17R)-17-ethyloxacycloheptadecan-2-one
- distinct musk odour: pleasant powdery and
slightly fresh
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NA
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(14S)-14-Ethyl-11-methylideneoxacyclotetradecan-2-one
- weak musk odour with a musty-woody tonality
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NA
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(14R)-14-Ethyl-11-methylideneoxacyclotetradecan-2-one
- strong musk note, fresh and clearly woody with
cedarwood-like aspects
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NA
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