Chirality & Odour Perception
John C. Leffingwell, Ph.D.

The 8-tert-butylbicyclo[4.4.0]decan-3-ols

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Photo by permission of M. Roudintska - Art & Parfum

(+)-(1S,3R,6R,8R)-8-tertbutylbicyclo[4.4.0]decan-3-ol - strong, sandalwood like, warm, sweet and fatty, long persisting,

Ref: Buchbauer, G., Spreitzer, H., Swatonek, H., Wolschann, P. Absolute Configuration and Odour Analysis of the Enantiomeric tert-Butyl-bicyclo[4.4.0]decan-3-ols. Tetrahedron: Asymmetry 3:197–198, 1992; Witteveen, Jan G.; Weerdt, Anton J. A. van der, Structure-odour relationships of some new synthetic sandalwood aroma chemicals. Synthesis and olfactive properties in a series of bicyclo[4.4.0]decan-3-ols, Recl. Trav. Chim. Pays-Bas, 1987, 106: (1) 29-34

(-)-(1R,3S,6S,8S)-8-tertbutylbicyclo[4.4.0]decan-3-ol - very weak, fatty, hardly perceptible, remote reminiscent to animal notes.

Ref: Buchbauer, G., Spreitzer, H., Swatonek, H., Wolschann, P. Absolute Configuration and Odour Analysis of the Enantiomeric tert-Butyl-bicyclo[4.4.0]decan-3-ols. Tetrahedron: Asymmetry 3:197–198, 1992; Witteveen, Jan G.; Weerdt, Anton J. A. van der, Structure-odour relationships of some new synthetic sandalwood aroma chemicals. Synthesis and olfactive properties in a series of bicyclo[4.4.0]decan-3-ols, Recl. Trav. Chim. Pays-Bas, 1987, 106: (1) 29-34

Cyclic Terpenoid Odorants

Bicyclic Terpenoid Odorants

Acyclic Terpenoid Odorants

Ionones, Irones, Damascones & Structurally Related Odorants

Acyclics (Alcohols, Esters, Acids, Aldehydes)

Lactones

Sesquiterpenoid Related Odorants

Steroid Urine Type Odorants

Sandalwood Type Odorants

Musk Odorants

Miscellaneous

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