The delta-Octathionolactones

Chirality & Odour Perception
John C. Leffingwell, Ph.D.

The 1-hydroxy-1,4,7,7,9-pentamethylspiro[4.5]decan-2-ones

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Photo by permission of M. Roudintska - Art & Parfum

(+)-(1S,4R,5R,9S)-1-hydroxy-1,4,7,7,9-pentamethylspiro[4.5]decan-2-one - Powerful patchouli-like odor

Odor threshold = 0.067 ng/L air for racemate

Ref: Philip Kraft, Walter Eichenberger, David Frech, From Vetiver to Patchouli: Discovery of a NewHigh-Impact Spirocyclic Patchouli Odorant, European Journal of Organic Chemistry, Volume 2005, Issue 15, Date: August 2005, Pages: 3233-3245

(-)-(1R,4S,5S,9R)-1-hydroxy-1,4,7,7,9-pentamethylspiro[4.5]decan-2-one - Odorless

Ref: Philip Kraft, Walter Eichenberger, David Frech, From Vetiver to Patchouli: Discovery of a NewHigh-Impact Spirocyclic Patchouli Odorant, European Journal of Organic Chemistry, Volume 2005, Issue 15, Date: August 2005, Pages: 3233-3245

Cyclic Terpenoid Odorants

Bicyclic Terpenoid Odorants

Acyclic Terpenoid Odorants

Ionones, Irones, Damascones & Structurally Related Odorants

Acyclics (Alcohols, Esters, Acids, Aldehydes)

Lactones

Sesquiterpenoid Related Odorants

Steroid Urine Type Odorants

Sandalwood Type Odorants

Musk Odorants

Miscellaneous

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